Shades of light they manage for the first time to grasp the molecular footprints from the Most hidden brain areas and difficult to reach and, thanks to this information, it becomes possible study and understand The most complex of organs. The result is published in the magazine Nature Methods with the coordination of the Physics and Astronomy Department of the University of Padua and the Italian Institute of Technology (IIT) with the Centers of Lecce and Genoa. The universities of Salento, ‘Magna Graecia’ of Catanzaro and the Polytechnic of Bari, was attended, as well as the Cajal Institute of Madrid.
“The technique we used uses one characteristic particular, albeit elusive, ofLight-Maria interaction“Says the first author of the research Filippo Pisano, of the University of Padua and the IIT center of Arnesano (Lecce).“ When a light beamof a Very well defined coloraffects one molecule – he continues – one minimal part of energy light trigger from the vibrations in the molecule.
Immediately after, one small portion of light beam it is spread with one slight alteration of the initial color. Measure this shade of color provide valuable information on the chemical structure of the affected moleculewithout the need to use external markers “.
The new technique, non -invasive and that does not use contrast media or markers of any kind, opens one new road in brain research, Based on the science that studies the light and the way in which it interacts with the subject (photonic). The phenomenon that exploits is called diffusion raman And “it has already been employed in the study of biological tissues, with some recent clinical applications”, observes Ferruccio Pisanello, coordinator of the Center for Biomolecular Nanotechnology of Iit in Lecce. “For the first time – he adds – We managed to carry out recordings in deep brain areas, minimizing the tissue damage. This was possible thanks unconventional combination Of light in the nearby infraredwith Planting optical fibers, microscopes specially designed, e Advanced techniques Of data analysisincluding artificial intelligence algorithms “.
For another author of the research, Massimo De Vittorio of the University of Salento and the Iit of Lecce, “although still far from applications medicalthis Methodology discounts new possibilities for one deeper understanding of cerebral physiology that hypothesizes promising applications on the study of pathological neurological conditions, such as i brain tumors he is cranial trauma“.
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