Clean up there network of blood vessels That surrounds externally The brain improves the capacity of the most complex of organs e the keeps young: is the discovery made on the mice by the study led by Kyungdeok Kim, of the University of Washington in St. Louis, and published in the Cell magazine. The result could help develop New therapies To counteract pathologies such as theAlzheimer.
Bring drugs to cells inside the brain human is one challenge practically impossible because the brain is protected by a sort of impenetrable security service, called blood barrierwhich rigorously controls everything that could pass through the blood vessels and prevents the passage of unwanted molecules.
The recent discovery of a network of blood vessels outside the braincalled Lymphatic vases of the Meninxcould prove to be useful for giving indirect support to the correct functioning of the brain cells. The researchers have in fact tested one on the mice molecule capable of enhance the growth of these vases external lymphatics, in order to Promote drainage and the elimination of molecular waste typical of thenoise from the cell.
Cognitive tests on the treated elderly mice show that the development of the external vessels has allowed to improve memory. “Take the most easily accessible lymphatic vases that are outside the brain – said Jonathan Kipnis, one of the coordinators of the study – could prove to be a new exciting frontier in treatment of brain disorders“.
According to researchers, the improvements in memory would be due to one more effective elimination of waste Even by brain neurons not directly touched by the most external blood vessel network. Improve waste ‘traffic’ in the external network would make so The elimination of waste also from the network is more effective Beyond the hematencephalic barrier. “We are unable to bring neurons back to life – added Kipnis – but we could be able to guarantee theirs more optimal operation through the modulation of the lymphatic vases of the meninx “.
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