Allows the body to independently produce its own medicine, the first permanent therapy For lose weight which eliminates the need to regularly undergo injections: it was successfully experienced on mice and is based on an innovative approach toGenetic editing that instead of correct a mutation harmful introduces a new gene into the DNA coding for one protein. The results are published in the Comunications Medicine magazine by a research group of the University of Osaka.
Researchers coordinated by Keiichiro Suzuki have genetically modified obese mice and affected by pre-diabetes introducing a gene capable of producing exenatide: a drug used for type 2 diabetes therapy that stimulates pancreas to produce insulin and therefore helps to keep sugar levels under control in the blood. Thanks to its action, this drug, which must be injected, can also help you lose weight.
“The results were really exciting – says Suzuki – we discovered that the modified genome mice produced high levels of exenatids detectable in the blood for several months after the introduction of the gene”. The animals thus treated in addition to lose weight they also showed less appetitea more efficient glucose metabolism and greater insulin sensitivity. This approach could become one Valid alternative to classic genetic editing Especially as regards all those disorders that are not caused by a single mutation but by a set of different factors such as obesity, diabetes and heart disease.
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