One has been identified new weapon To combat the most aggressive brain cancer, glioblastoma. It is an enzyme, that is, a protein that accelerates chemical reactions, and plays a key role in the process that allows the tumor to grow rapidly. The discovery, published in the magazine Science Advances, is due to research coordinated by the Ohio State University Cancer Center for Cancer Research. THE’enzyme now becomes a objective of possible therapies More effective against a tumor for which, at the moment, there are very few treatments available.
The glioblastoma is a Quick growth cerebral tumor which develops starting from Gliali cells of the brain, those that support and support neurons, and it is estimated that it affects about 15 thousand people every year. “Glioblastoma is the most lethal brain tumor, with an average survival of only 12-16 months from the moment of diagnosis despite the therapies”, observes Huali su, first signatory of the study coordinated by Deliang Guo: “There is urgent need – adds on – of new molecular targets for this disease “.
The enzyme identified by the researchers is called PGM3 and is involved in the reaction that produces theexosaminea molecule that attacks protein and fat sugars allowing tumors to grow quickly. According to researchers, hitting PGM3 with specific treatments would allow Reduce the expansion of glioblastoma And to make its cells die: “block the enzyme PGM3 – says Guo – could stop the connection between sugars, proteins and fats in the cells, helping to stop the growth of the tumor”.
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