Discovered theUnexpected double work of a protein crucial for cells, called DDX11: in addition to playing the role of the mechanic in the nucleus of the cell, where opens the double propeller of the DNA To allow it to replication and the repairalso works as a cytoplasm for cytoplasm for region The waste recycling. This is indicated by the study conducted by the Institute of Biochemistry and Cellular Biology of the National Research Council in collaboration with the University of Naples Federico II. The results, published in the Autophagy magazine, open the road to New strategies against rare genetic diseases And neurodegenerative as Parkinson’s And Alzheimer.
There DDX11 protein it was already note for some time for its function of DNA Elicasiswhich sees her operate in the cell nucleus To separate the two filaments of the double helix and thus allow the intervention of the proteins that deal with the replication and of the repair. The researchers have now discovered that it is Also active in the cytoplasm cells, where it is involved in the Autophagy adjustmentthe process with which they are recycled staff and proteins, damaged and no longer functioning.
“We observed that, In the absence of DDX11the cells lose the ability to correctly form autophagosomesthe ‘shuttles’ that transport cellular waste to lysosomes for degradation: this compromises the removal of toxic aggregates “, observes Raffaella Bonavita, the first author of the study. Another key element emerged from the study concerns theInteraction between DDX11 and Protein P62/SQSTM1a fundamental receptor for selecting and loading proteins and oriental staff in autophygosomes.
THE’autophagy is now considered a essential mechanism for the Health of the nervous system And its alteration has been connected to numerous Neurodegenerative diseasesincluding Parkinson’s, Alzheimer, ALS And Ataxia with type 2 oculomotor apraxia. The direct involvement of DDX11 in this process opens completely unpublished perspectivesboth for rare genetic diseases such as the Warsaw Breakage Syndromewhich compromises physical and neurological development, both for Neurodegenerative diseases.
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